Title : HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD.

Pub. Date : 2017 Oct 17

PMID : 29042644






1 Functional Relationships(s)
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1 Diminished hepatic fatty acid ss-oxidation was associated with decreased mRNA expression of Pparalpha and its targets Cpt1, Aox, Lcad, Ehhadh, Hsd10 and Acaa2, and blunted VLDL export with decreased expression of Mttp and its product microsomal triglyceride transfer protein. hepatic fatty acid carnitine palmitoyltransferase 1A Homo sapiens