Title : Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM.

Pub. Date : 2017 Oct 24

PMID : 29035201






2 Functional Relationships(s)
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1 Here, we present a cryo-EM structure of a hamster SUR1/rat Kir6.2 channel bound to a high-affinity sulfonylurea drug glibenclamide and ATP at 3.63 A resolution, which reveals unprecedented details of the ATP and glibenclamide binding sites. Adenosine Triphosphate ATP binding cassette subfamily C member 8 Homo sapiens
2 Here, we present a cryo-EM structure of a hamster SUR1/rat Kir6.2 channel bound to a high-affinity sulfonylurea drug glibenclamide and ATP at 3.63 A resolution, which reveals unprecedented details of the ATP and glibenclamide binding sites. Adenosine Triphosphate ATP binding cassette subfamily C member 8 Homo sapiens