Pub. Date : 2017 Nov 15
PMID : 29022012
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we investigated the underlying relationship between the oxidant-sensitive mitogen-activated protein kinase (MAPK) signaling pathway and vanadium-induced oxidative stress in oviduct magnum epithelial (OME) cells. | Vanadium | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Likewise, MAPK inhibitors effectively suppressed vanadium-induced apoptosis and ROS generation (P < 0.05). | Vanadium | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Incubation of OME cells with MAPK inhibitors also prevents malondialdehyde concentration increase and lactic dehydrogenase activity decrease in response to vanadium (P < 0.05). | Vanadium | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Vanadium downregulated P38, ERK1/2, JNK, Nrf2, sMaf, GCLC, NQO1 and HO-1 mRNA expression (P < 0.05). | Vanadium | mitogen-activated protein kinase 3 | Homo sapiens |