Title : Macrolides Blunt Aldosterone Biosynthesis: A Proof-of-Concept Study in KCNJ5 Mutated Adenoma Cells Ex Vivo.

Pub. Date : 2017 Dec

PMID : 28993452






1 Functional Relationships(s)
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1 We found that clarithromycin concentration dependently lowered CYP11B2 gene expression (by 60%) and aldosterone secretion (by 70%; P<0.001 for both) in CD56+ cells isolated ex vivo from KCNJ5 mutated APAs, although it was ineffective in CD56+ cells from wild-type APAs. Clarithromycin cytochrome P450 family 11 subfamily B member 2 Homo sapiens