Title : The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study.

Pub. Date : 2018 Sep 1

PMID : 28993240






3 Functional Relationships(s)
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1 Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
3 In conclusion, the results of the present study indicate a negligible reactivation of soman-inhibited AChE by oximes at conditions simulating the in vivo poisoning by soman. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens