Title : Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming.

Pub. Date : 2017 Sep 15

PMID : 28978059






2 Functional Relationships(s)
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1 We also found that inhibiting NADPH production through knockdown of 6-phosphogluconate dehydrogenase (6PGD) within the pentose phosphate pathway was sufficient to reduce cell growth and lactate production, a measure of metabolic reprogramming. Lactic Acid phosphogluconate dehydrogenase Homo sapiens
2 We also found that inhibiting NADPH production through knockdown of 6-phosphogluconate dehydrogenase (6PGD) within the pentose phosphate pathway was sufficient to reduce cell growth and lactate production, a measure of metabolic reprogramming. Lactic Acid phosphogluconate dehydrogenase Homo sapiens