Title : Structure-Activity Studies of N-Butyl-1-deoxynojirimycin (NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2.

Pub. Date : 2017 Dec 7

PMID : 28975712






3 Functional Relationships(s)
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1 Analogues of N-butyl-1-deoxynojirimycin (NB-DNJ) were prepared and assayed for inhibition of ceramide-specific glucosyltransferase (CGT), non-lysosomal beta-glucosidase 2 (GBA2) and the lysosomal beta-glucosidase 1 (GBA1). miglustat UDP glycosyltransferase 8 Homo sapiens
2 Analogues of N-butyl-1-deoxynojirimycin (NB-DNJ) were prepared and assayed for inhibition of ceramide-specific glucosyltransferase (CGT), non-lysosomal beta-glucosidase 2 (GBA2) and the lysosomal beta-glucosidase 1 (GBA1). miglustat UDP glycosyltransferase 8 Homo sapiens
3 Analogues of N-butyl-1-deoxynojirimycin (NB-DNJ) were prepared and assayed for inhibition of ceramide-specific glucosyltransferase (CGT), non-lysosomal beta-glucosidase 2 (GBA2) and the lysosomal beta-glucosidase 1 (GBA1). miglustat UDP glycosyltransferase 8 Homo sapiens