Title : Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells.

Pub. Date : 2017 Sep

PMID : 28970848






3 Functional Relationships(s)
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1 Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Furthermore, CFE attenuated the TPA-induced activation of AP-1. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 CONCLUSION: The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C delta/p38/c-Jun N-terminal kinase/AP-1 pathway. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens