Title : Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity.

Pub. Date : 2017 Sep 8

PMID : 28969043






1 Functional Relationships(s)
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1 Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK. Isothiocyanates Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens