Pub. Date : 2018 Feb
PMID : 28963785
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Moreover, nicotine induced Akt degradation via UPS, and Akt overexpression blocked nicotine-induced apoptosis in HUVECs cultured in HG/HF media. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Moreover, nicotine induced Akt degradation via UPS, and Akt overexpression blocked nicotine-induced apoptosis in HUVECs cultured in HG/HF media. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Furthermore, the TTC3 and MUL1 shRNA adenovirus dramatically decreased the Akt ubiquitination and apoptosis induced by nicotine. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | These results indicate that nicotine-induced Akt ubiquitination and degradation occurs through TTC3 and MUL1 and results in a dramatic increase in apoptosis in HUVECs cultured in HG/HF media. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |