Pub. Date : 2017 Sep 29
PMID : 28963468
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Here, we demonstrate that the leucine sensor function for mTORC1 activation of LRS can be decoupled from its catalytic activity. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | These findings suggest new strategies for controlling tumor growth that avoid the resistance to existing mTOR inhibitors resulting from cancer-associated MTOR mutations.Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Here, the authors identify inhibitors of the GTPase activating function of LRS, not affecting its catalytic activity, and demonstrate that the leucine sensor function of LRS can be a new target for mTORC1 inhibition. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |