Pub. Date : 2015
PMID : 28962480
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study was designed to evaluate whether glycogen synthase kinase-3beta (GSK-3beta) inhibitor, 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8) induced the the expression of connexin 43 (Cx43) to protect against renal ischemia-reperfusion (I/R) injury (RI/RI) in rats. | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | gap junction protein, alpha 1 | Rattus norvegicus |
| 2 | This study was designed to evaluate whether glycogen synthase kinase-3beta (GSK-3beta) inhibitor, 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8) induced the the expression of connexin 43 (Cx43) to protect against renal ischemia-reperfusion (I/R) injury (RI/RI) in rats. | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | gap junction protein, alpha 1 | Rattus norvegicus |
| 3 | The results indicated that TDZD-8 improved the recovery of renal function, reduced oxidative stress and inflammation injury, and upregulated the expression of (Cx43) as compared to I/R group. | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | gap junction protein, alpha 1 | Rattus norvegicus |
| 4 | Therefore, our study demonstrated that TDZD-8 provided a protection to the kidney against I/R injury in rats through inducing the expression of (Cx43). | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | gap junction protein, alpha 1 | Rattus norvegicus |