Title : In Vitro Assessment of the Effect of Antiepileptic Drugs on Expression and Function of ABC Transporters and Their Interactions with ABCC2.

Pub. Date : 2017 Sep 29

PMID : 28961159






2 Functional Relationships(s)
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1 phenytoin, carbamazepine, valproate, lamotrigine, topiramate and levetiracetam, on the expression and function of ABCB1, ABCC1, ABCC2 and ABCG2 in Caco2 and HepG2 cell lines through real time PCR, western blot and functional activity assays. Valproic Acid ATP binding cassette subfamily B member 1 Homo sapiens
2 Valproate caused a significant increase in the expression and functional activity of ABCB1 in HepG2 only. Valproic Acid ATP binding cassette subfamily B member 1 Homo sapiens