Title : The effect of antipyrine and rifampicin on the excretion of renal enzymes in human urine.

Pub. Date : 1988 Feb

PMID : 2896083






3 Functional Relationships(s)
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1 Antipyrine plasma clearance and 6-beta-OHF excretion rates increased significantly in the groups treated with antipyrine or rifampicin, while serum GGT activities were enhanced only following antipyrine. Antipyrine gamma-glutamyltransferase light chain family member 3 Homo sapiens
2 Antipyrine administration increased urinary GGT excretion both immediately and one week after cessation of drug administration, but no changes were found following the administration of rifampicin. Antipyrine gamma-glutamyltransferase light chain family member 3 Homo sapiens
3 Based on these findings, the increased urinary GGT excretion observed following antipyrine treatment may be due to an inducing effect on the renal tubular cells, as no evidence for a toxic renal damage was found. Antipyrine gamma-glutamyltransferase light chain family member 3 Homo sapiens