Pub. Date : 2017 Dec
PMID : 28960344
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: Ritonavir and cobicistat are strong inhibitors of human cytochrome P450-3A (CYP3A) isoforms, and are used clinically as pharmacokinetic boosting agents for other antiretroviral drugs. | Ritonavir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | OBJECTIVES: Ritonavir and cobicistat are strong inhibitors of human cytochrome P450-3A (CYP3A) isoforms, and are used clinically as pharmacokinetic boosting agents for other antiretroviral drugs. | Ritonavir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | KEY FINDINGS: Ritonavir and cobicistat both were strong inhibitors of CYP3A4, with IC50 values of 0.014 and 0.032 mum, respectively. | Ritonavir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | CONCLUSIONS: Consistent with previous reports, both ritonavir and cobicistat were highly potent inhibitors of CYP3A. | Ritonavir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |