Title : Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Pub. Date : 2017 Oct 5

PMID : 28953875






1 Functional Relationships(s)
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1 We present a high resolution (1.95 A) co-crystal structure of a small molecule bound to the catalytic active site of p300 and demonstrate that A-485 competes with acetyl coenzyme A (acetyl-CoA). Acetyl Coenzyme A E1A binding protein p300 Homo sapiens