Title : The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia.

Pub. Date : 2017 Nov

PMID : 28952835






2 Functional Relationships(s)
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1 The results indicated that treatment with the selective SIRT1 inhibitor EX-527 suppressed LPS-induced elevation of TNF-alpha and IL-6 in plasma. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide interleukin 6 Mus musculus
2 Meanwhile, the inhibitory effects of EX-527 on IL-6 induction and the beneficial effects of EX-527 on lung injury were partially reversed by 3BDO. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide interleukin 6 Mus musculus