Pub. Date : 2017 Nov 15
PMID : 28928082
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin. | Fluorouracil | tumor protein p53 | Homo sapiens |
| 2 | Evidence demonstrate that p53 mutations and microRNAs (miRs) are important components of 5-FU resistance in colorectal cancer (CRC). | Fluorouracil | tumor protein p53 | Homo sapiens |
| 3 | Moreover, inhibition of miR-338-3p in HT29 and HCT116 p53-/- cells increased their sensitivity to 5-FU treatment. | Fluorouracil | tumor protein p53 | Homo sapiens |
| 4 | Our results reveal a critical and novel role of miR-338-3p in the correlation of 5-FU resistance with p53 status. | Fluorouracil | tumor protein p53 | Homo sapiens |
| 5 | Moreover, the miR-338-3p inhibitor has the potential to overcome 5-FU resistance in p53 mutant colon cancer cells. | Fluorouracil | tumor protein p53 | Homo sapiens |