Pub. Date : 2017 Sep
PMID : 28927780
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibited ERK1/2, JNK, and PI3K/Akt, but activated p38 pathway in these two cells. | Metformin | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | The combination of specific inhibitors of ERK1/2, JNK or PI3K/Akt pathway and metformin further promoted cell apoptosis and the up-regulation of p21, Bax, Bad, cleaved caspase-3 and -9 as well as the down-regulation of Bcl-2 mediated by metformin alone, but inhibition of p38 pathway exhibited the opposite results. | Metformin | mitogen-activated protein kinase 3 | Homo sapiens |