Pub. Date : 2018 Jun
PMID : 28926094
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling. | Curcumin | tumor protein p53 | Homo sapiens |
| 2 | In this study, we aimed to investigate the effects of curcumin on cell activities of gastric cancer (GC), and the connection between curcumin and P53, as well as, PI3K signaling. | Curcumin | tumor protein p53 | Homo sapiens |
| 3 | Western blot assay was also employed to detect impacts of curcumin on tophosphatidylinositol-3 kinase (PI3K) and P53 signaling pathways-related proteins. | Curcumin | tumor protein p53 | Homo sapiens |
| 4 | Western blot results showed that curcumin activated P53 signaling pathway and inhibited PI3K signaling pathway. | Curcumin | tumor protein p53 | Homo sapiens |
| 5 | Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR. | Curcumin | tumor protein p53 | Homo sapiens |
| 6 | Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR. | Curcumin | tumor protein p53 | Homo sapiens |