Title : TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease.

Pub. Date : 2017 Oct 3

PMID : 28923922






1 Functional Relationships(s)
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1 Accordingly, MAO-B inhibitor rasagiline disrupts alpha-Syn/TrkB complex and rescues TrkB neurotrophic signaling, preventing alpha-Syn-induced dopaminergic neuronal death and restoring motor functions. rasagiline monoamine oxidase B Homo sapiens