Title : A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition.

Pub. Date : 2017 Sep

PMID : 28904082






3 Functional Relationships(s)
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1 We tested the hypothesis that reduced availability of the endothelial nitric oxide synthase [eNOS] substrate L-arginine is an underlying mechanism to vascular endothelial dysfunction across menopause stages. Arginine nitric oxide synthase 3 Homo sapiens
2 We tested the hypothesis that reduced availability of the endothelial nitric oxide synthase [eNOS] substrate L-arginine is an underlying mechanism to vascular endothelial dysfunction across menopause stages. Arginine nitric oxide synthase 3 Homo sapiens
3 The relative L-arginine deficiency may be related to elevated levels of the methylarginine L-NMMA, which would compete with L-arginine for eNOS and for intracellular transport, reducing NO biosynthesis. Arginine nitric oxide synthase 3 Homo sapiens