Title : Defective distal regulatory element at the 5' upstream of rat prolactin gene of steroid-nonresponsive GH-subclone.

Pub. Date : 1987 Dec 8

PMID : 2890379






6 Functional Relationships(s)
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1 Defective distal regulatory element at the 5" upstream of rat prolactin gene of steroid-nonresponsive GH-subclone. Steroids prolactin Rattus norvegicus
2 In this investigation we have examined the 5" end flanking region of rat prolactin (rat PRL) gene of steroid-responsive, GH4C1 cells to identify the positive and negative regulatory elements and to verify the status of these elements in steroid-nonresponsive F1BGH12C1 cells. Steroids prolactin Rattus norvegicus
3 In this investigation we have examined the 5" end flanking region of rat prolactin (rat PRL) gene of steroid-responsive, GH4C1 cells to identify the positive and negative regulatory elements and to verify the status of these elements in steroid-nonresponsive F1BGH12C1 cells. Steroids prolactin Rattus norvegicus
4 In this investigation we have examined the 5" end flanking region of rat prolactin (rat PRL) gene of steroid-responsive, GH4C1 cells to identify the positive and negative regulatory elements and to verify the status of these elements in steroid-nonresponsive F1BGH12C1 cells. Steroids prolactin Rattus norvegicus
5 Results presented in this report demonstrate that the basel level expression of the co-transferred Neo gene (neomycin phosphoribosyl transferase) is modulated by the distal upstream regulatory elements of rat PRL gene in response to steroid hormones. Steroids prolactin Rattus norvegicus
6 We report here the identification of the distal steroid regulatory element (SRE) located between 3.8 and 7.8 kb upstream of the transcription initiation site of rat PRL gene. Steroids prolactin Rattus norvegicus