Title : Inhibition of Y1 receptor signaling improves islet transplant outcome.

Pub. Date : 2017 Sep 8

PMID : 28887564






1 Functional Relationships(s)
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1 Mechanistically, Y1 receptor signaling inhibits the production of cAMP in islets, which via CREB mediated pathways results in the down-regulation of several key enzymes in glycolysis and ATP production. Adenosine Triphosphate cAMP responsive element binding protein 1 Mus musculus