Pub. Date : 2017 Oct
PMID : 28882992
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites. | ponatinib | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Ponatinib exposure was significantly decreased in treated mice compared with controls (7.7- and 2.2-fold for WT and humanized CYP1A1/2, respectively). | ponatinib | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | These results indicate that not only could CYP1A1 be involved in ponatinib disposition, which has not been previously reported, but also that electrophilic intermediates resulting from CYP1A1 metabolism in normal tissues may contribute to ponatinib toxicity. | ponatinib | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 4 | These results indicate that not only could CYP1A1 be involved in ponatinib disposition, which has not been previously reported, but also that electrophilic intermediates resulting from CYP1A1 metabolism in normal tissues may contribute to ponatinib toxicity. | ponatinib | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 5 | These results indicate that not only could CYP1A1 be involved in ponatinib disposition, which has not been previously reported, but also that electrophilic intermediates resulting from CYP1A1 metabolism in normal tissues may contribute to ponatinib toxicity. | ponatinib | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |