Title : Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure.

Pub. Date : 2017 Dec 1

PMID : 28859968






2 Functional Relationships(s)
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1 Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure. saxagliptin dipeptidyl peptidase 4 Homo sapiens
2 We found that the primary target of saxagliptin, dipeptidyl peptidase-4, is absent in cardiomyocytes, yet saxagliptin internalized into cardiomyocytes and impaired cardiac contractility via inhibition of the Ca2+/calmodulin-dependent protein kinase II-phospholamban-sarcoplasmic reticulum Ca2+-ATPase 2a axis and Na+-Ca2+ exchanger function in Ca2+ extrusion. saxagliptin dipeptidyl peptidase 4 Homo sapiens