Pub. Date : 2017 Dec 1
PMID : 28859968
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure. | saxagliptin | dipeptidyl peptidase 4 | Homo sapiens |
| 2 | We found that the primary target of saxagliptin, dipeptidyl peptidase-4, is absent in cardiomyocytes, yet saxagliptin internalized into cardiomyocytes and impaired cardiac contractility via inhibition of the Ca2+/calmodulin-dependent protein kinase II-phospholamban-sarcoplasmic reticulum Ca2+-ATPase 2a axis and Na+-Ca2+ exchanger function in Ca2+ extrusion. | saxagliptin | dipeptidyl peptidase 4 | Homo sapiens |