Title : P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.

Pub. Date : 2017 Aug 29

PMID : 28851987






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we describe p53-dependent control of the rate-limiting enzyme in the pyrimidine catabolic pathway, dihydropyrimidine dehydrogenase (DPYD) and its effect on pharmacokinetics of and response to 5-fluorouracil (5-FU). pyrimidine tumor protein p53 Homo sapiens
2 Our data suggest that p53 plays an important role in controlling pyrimidine catabolism through repression of DPYD expression, following metabolic stress imposed by nucleotide imbalance. pyrimidine tumor protein p53 Homo sapiens