Pub. Date : 2017 Aug 29
PMID : 28851903
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PrPC is expressed on the basolateral membrane of retinal-pigment-epithelial (RPE) cells, where it mediates uptake of iron by the neuroretina. | Iron | prion protein | Mus musculus |
| 2 | Accordingly, the neuroretina of PrP-knock-out mice is iron-deficient. | Iron | prion protein | Mus musculus |
| 3 | In RPE19 cells, silencing of PrPC decreases ferritin while over-expression upregulates ferritin and divalent-metal-transporter-1 (DMT-1), indicating PrPC-mediated iron uptake through DMT-1. | Iron | prion protein | Mus musculus |
| 4 | Polarization of RPE19 cells results in upregulation of ferritin by ~10-fold and beta-cleavage of PrPC, the latter likely to block further uptake of iron due to cleavage of the ferrireductase domain. | Iron | prion protein | Mus musculus |