Pub. Date : 2018 Jan
PMID : 28851073
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of HER3/HER4 and activation of HER3/HER4-ERK pathway was shown to be involved in 4-PBA-induced gastric cancer cell migration. | 4-phenylbutyric acid | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Consistently, the ERK inhibitor PD98059 also partially prevented 4-PBA-induced cell migration. | 4-phenylbutyric acid | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | These results demonstrate that 4-PBA promotes gastric cancer cells migration through upregulation of HER3/HER4 subsequent to increased levels of acetyl-histone and activation of ERK signaling. | 4-phenylbutyric acid | mitogen-activated protein kinase 1 | Homo sapiens |