Title : The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.

Pub. Date : 2017

PMID : 28848393






1 Functional Relationships(s)
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1 The P2X7 receptor was implicated in the mechanosensitive priming of IL-1beta mRNA in vivo, as the antagonist Brilliant Blue G (BBG) blocked the increased expression, the agonist BzATP mimicked the pressure-dependent rise in IL-1beta, and the rise was absent in P2X7 knockout mice. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate interleukin 1 beta Mus musculus