Title : Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?

Pub. Date : 2018 Feb

PMID : 28844085






2 Functional Relationships(s)
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Protein Name
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1 Nicotinamide, a PARP-1 inhibitor, protects against the metabolic cascade elicited by the primary stage, avoiding NAD+ exhaustion and the energetic crisis. Niacinamide poly (ADP-ribose) polymerase 1 Rattus norvegicus
2 Here, we discuss evidence showing that (i) inhibition of PARP-1 overactivation by nicotinamide and (ii) inhibition of extrasynaptic NMDA receptor overactivation by memantine can prevent the short- and long-term consequences of PA. Niacinamide poly (ADP-ribose) polymerase 1 Rattus norvegicus