Title : Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.

Pub. Date : 2017

PMID : 28841710






1 Functional Relationships(s)
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1 Inhibition of ROCK kinase activity by a small molecule inhibitor (fasudil) resulted in moderate (IC50s of 6-71 muM) inhibition of PDAC cell proliferation, migration, and activation of co-cultured stellate cells. fasudil Rho associated coiled-coil containing protein kinase 1 Homo sapiens