Pub. Date : 2017
PMID : 28831207
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior. | resiniferatoxin | tumor necrosis factor | Rattus norvegicus |
| 2 | We examined the effect of intrathecal administration of the ultrapotent TRPV1 agonist resiniferatoxin (RTX) on TNF-induced pain-associated behavior of rats using von Frey and hot plate behavioral testing. | resiniferatoxin | tumor necrosis factor | Rattus norvegicus |
| 3 | We examined the effect of intrathecal administration of the ultrapotent TRPV1 agonist resiniferatoxin (RTX) on TNF-induced pain-associated behavior of rats using von Frey and hot plate behavioral testing. | resiniferatoxin | tumor necrosis factor | Rattus norvegicus |
| 4 | The additional intrathecal administration of RTX (1.9 mug/kg) alleviates TNF-induced mechanical allodynia and thermal hyperalgesia 24 h after injection. | resiniferatoxin | tumor necrosis factor | Rattus norvegicus |
| 5 | These results suggest that the involvement of TRPV1 in TNF-induced pain offers new TRPV1-based experimental therapeutic approaches and demonstrates the analgesic potential of RTX in inflammatory pain diseases. | resiniferatoxin | tumor necrosis factor | Rattus norvegicus |