Title : A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.

Pub. Date : 2017 Aug 22

PMID : 28831021






1 Functional Relationships(s)
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1 However, only the two 11-hydroxy-epoxy-octadecenoates sensitized rat dorsal root ganglion neurons to release more calcitonin gene-related peptide (CGRP), which is involved in pain transmission, in response to low pH (which mimics an inflammatory state) or capsaicin (which activates ion channels involved in nociception). Capsaicin calcitonin-related polypeptide alpha Rattus norvegicus