Pub. Date : 1987 Feb 24
PMID : 2883013
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, rats were restrained for 2 h and injected with vehicle or 60-1,000 micrograms/kg of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) s.c. Vehicle-treated restrained rats showed reduced locomotor activity and increased defaecation in an open field test the day after the end of restraint. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 2 | Therefore, rats were restrained for 2 h and injected with vehicle or 60-1,000 micrograms/kg of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) s.c. Vehicle-treated restrained rats showed reduced locomotor activity and increased defaecation in an open field test the day after the end of restraint. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 3 | Evidence suggests that the above action of 8-OH-DPAT is mediated by 5-HT1A receptors since it was antagonised by the 5-HT1A antagonist spiperone but not by the 5-HT2 antagonist ketanserin and was not mimicked by the 5-HT1B agonist RU 24969. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 4 | Evidence suggests that the above action of 8-OH-DPAT is mediated by 5-HT1A receptors since it was antagonised by the 5-HT1A antagonist spiperone but not by the 5-HT2 antagonist ketanserin and was not mimicked by the 5-HT1B agonist RU 24969. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |