Pub. Date : 2017 Aug
PMID : 28827794
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH). | isocitric acid | Parkinsonism associated deglycase | Homo sapiens |
| 2 | In RNA-sequencing analyses searching for novel anti-oxidant genes downstream of DJ-1, a gene encoding NADP+-dependent isocitrate dehydrogenase (IDH), which converts isocitrate into alpha-ketoglutarate, was detected. | isocitric acid | Parkinsonism associated deglycase | Homo sapiens |
| 3 | Consistently, trimethyl isocitrate (TIC), a cell permeable isocitrate, protected mammalian DJ-1 null DA cells from oxidative stress in an IDH-dependent manner. | isocitric acid | Parkinsonism associated deglycase | Homo sapiens |