Title : A systematic review on the role of eicosanoid pathways in rheumatoid arthritis.

Pub. Date : 2018 Mar

PMID : 28818745






1 Functional Relationships(s)
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1 CONCLUSIONS: Extended research is necessary for the development of these novel compounds targeting the eicosanoid pathway, by increasing the levels of anti-inflammatory eicosanoids (PGD2,15dPGJ2), by inhibiting the production of pro-inflammatory eicosanoids (PGE2, LTB4, PGI2) involved in rheumatoid arthritis or also by developing dual compounds displaying both the COX-2 inhibitor/TP antagonist activity within a single compound. Eicosanoids mitochondrially encoded cytochrome c oxidase II Homo sapiens