Title : Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy.

Pub. Date : 2017 Oct

PMID : 28809097






3 Functional Relationships(s)
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1 The magnitude of changes in Ras BRaf binding force correlates with the size of alterations in protein affinity and in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate receptor (-R)-mediated synaptic transmission in neurons expressing replacement BRaf mutants, and predicts the extent of learning impairments in animals expressing replacement BRaf mutants. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid B-Raf proto-oncogene, serine/threonine kinase Homo sapiens
2 The magnitude of changes in Ras BRaf binding force correlates with the size of alterations in protein affinity and in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate receptor (-R)-mediated synaptic transmission in neurons expressing replacement BRaf mutants, and predicts the extent of learning impairments in animals expressing replacement BRaf mutants. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid B-Raf proto-oncogene, serine/threonine kinase Homo sapiens
3 The magnitude of changes in Ras BRaf binding force correlates with the size of alterations in protein affinity and in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate receptor (-R)-mediated synaptic transmission in neurons expressing replacement BRaf mutants, and predicts the extent of learning impairments in animals expressing replacement BRaf mutants. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid B-Raf proto-oncogene, serine/threonine kinase Homo sapiens