Title : The Rac GTPase in Cancer: From Old Concepts to New Paradigms.

Pub. Date : 2017 Oct 15

PMID : 28807941






1 Functional Relationships(s)
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1 This review examines the multiple mechanisms leading to Rac1 hyperactivation, particularly focusing on emerging paradigms that involve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 degradation, and mislocalization of Rac signaling components. Guanine Nucleotides Rac family small GTPase 1 Homo sapiens