Pub. Date : 2017
PMID : 28804558
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NADPH oxidase 2 inhibitor diphenyleneiodonium enhances ROS-independent bacterial phagocytosis in murine macrophages via activation of the calcium-mediated p38 MAPK signaling pathway. | diphenyleneiodonium | cytochrome b-245, beta polypeptide | Mus musculus |
| 2 | Here, we found that the classic NOX2 inhibitor diphenyleneiodonium (DPI) induced uptake of E. coli by murine peritoneal macrophages through enhancing phagocytosis, and this effect was temperature-sensitive and attenuated by cytochalasin D as well as chemical inhibition of Syk and PLCgamma, two downstream kinases involved in actin polymerization during phagocytosis. | diphenyleneiodonium | cytochrome b-245, beta polypeptide | Mus musculus |
| 3 | Here, we found that the classic NOX2 inhibitor diphenyleneiodonium (DPI) induced uptake of E. coli by murine peritoneal macrophages through enhancing phagocytosis, and this effect was temperature-sensitive and attenuated by cytochalasin D as well as chemical inhibition of Syk and PLCgamma, two downstream kinases involved in actin polymerization during phagocytosis. | diphenyleneiodonium | cytochrome b-245, beta polypeptide | Mus musculus |
| 4 | The DPI-induced enhancement of phagocytosis was independent of NOX2 inhibition or ROS generation but depended on increased intracellular calcium and activation of the p38 MAPK signaling pathway. | diphenyleneiodonium | cytochrome b-245, beta polypeptide | Mus musculus |