Title : Induction of senescence in cancer cells by 5'-Aza-2'-deoxycytidine: Bioinformatics and experimental insights to its targets.

Pub. Date : 2017 Oct

PMID : 28802167






2 Functional Relationships(s)
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1 Bioinformatics analyses predicted that 5-Aza-dC functions as a p53 inducer, radiosensitizer, and inhibitor of some enzymes. Decitabine tumor protein p53 Homo sapiens
2 In this study, we provide experimental evidence showing HDM2 is one of the targets of 5-AZA-dC leading to activation of p53 pathway and growth arrest of cells. Decitabine tumor protein p53 Homo sapiens