Title : Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.

Pub. Date : 2017 Oct 20

PMID : 28797883






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Molecular modeling and kinetic studies revealed that compound 7f was a mixed-type inhibitor, which bond simultaneously to CAS and PAS of AChE, and it was also a competitive inhibitor, which occupied the active site of MAO-B. Protactinium acetylcholinesterase Rattus norvegicus