Title : Design, synthesis and antiproliferative activity of novel substituted 2-amino-7,8-dihydropteridin-6(5H)-one derivatives.

Pub. Date : 2017 Sep 1

PMID : 28789892






1 Functional Relationships(s)
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1 The initial structure-activity relationship studies indicated that linker-length of amine chain in C-2 position of pyrimidine ring played a crucial role in modulating the antitumor activity, which could be of help in the rational design of dihydropteridin-6(5H)-ones as novel anticancer drugs. pyrimidine complement C2 Homo sapiens