Pub. Date : 2017
PMID : 28785378
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital. | Phenobarbital | 8-oxoguanine DNA-glycosylase 1 | Mus musculus |
2 | The carcinogenic potential of phenobarbital (PB) was assessed in a mouse line carrying a mutant Mmh allele of the Mmh/Ogg1 gene encoding the enzyme oxoguanine DNA glycosylase (Ogg1) responsible for the repair of 8-hydroxy-2"-deoxyguanosine (8-OHdG). | Phenobarbital | 8-oxoguanine DNA-glycosylase 1 | Mus musculus |
3 | Hepatocellular carcinomas (HCCs) were found in PB-treated Ogg1-/- mice, while Ogg1+/+ animals developed only hepatocellular adenomas (HCAs) at the same rate. | Phenobarbital | 8-oxoguanine DNA-glycosylase 1 | Mus musculus |
4 | This was coordinated with PB-induced significant elevation of 8-OHdG formation in DNA and cell proliferation in adjacent liver of Ogg1-/- mice. | Phenobarbital | 8-oxoguanine DNA-glycosylase 1 | Mus musculus |
5 | Treatment of Ogg1-/- mice with PB resulted in significant elevation of cell proliferation in the liver. | Phenobarbital | 8-oxoguanine DNA-glycosylase 1 | Mus musculus |
6 | These results indicate that PB induced progression from HCA to HCC in Ogg1-/- mice, due to persistent accumulation of DNA oxidative base modifications and suppression of Nrf2-mediated oxidative stress response, resulting in significant elevation of cell proliferation. | Phenobarbital | 8-oxoguanine DNA-glycosylase 1 | Mus musculus |