Pub. Date : 2017 Aug
PMID : 28781617
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The results indicated that IL-32alpha exposure enhanced the lipid deposition and attenuated the cholesterol efflux from ox-LDL-stimulated THP-1 macrophages in a dose-dependent manner. | Cholesterol | GLI family zinc finger 2 | Homo sapiens |
| 2 | Addition of the PPARgamma agonist 15d-PGJ2 or overexpression of PPARgamma in THP-1 macrophages abrogated the IL-32alpha-mediated inhibition of cholesterol efflux and reversed the IL-32alpha-mediated downregulation of ABCA1 and LXRalpha. | Cholesterol | GLI family zinc finger 2 | Homo sapiens |
| 3 | In conclusion, IL-32alpha enhances lipid accumulation and inhibits cholesterol efflux from ox-LDL-exposed THP-1 macrophages by regulating the PPARgamma-LXRalpha-ABCA1 pathway. | Cholesterol | GLI family zinc finger 2 | Homo sapiens |