Title : TGF-β1 stimulates cyclooxygenase-2 expression and PGE2 production of human dental pulp cells: Role of ALK5/Smad2 and MEK/ERK signal transduction pathways.

Pub. Date : 2017 Oct

PMID : 28779848






4 Functional Relationships(s)
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1 TGF-beta1 stimulates cyclooxygenase-2 expression and PGE2 production of human dental pulp cells: Role of ALK5/Smad2 and MEK/ERK signal transduction pathways. Dinoprostone transforming growth factor beta 1 Homo sapiens
2 The purposes of this study were to investigate the differential signal transduction pathways of TGF-beta1 that mediate COX-2 stimulation and PGE2 production in dental pulp cells. Dinoprostone transforming growth factor beta 1 Homo sapiens
3 Exposure to TGF-beta1 (0.1-10 ng/mL) significantly stimulated PGE2 production of dental pulp cells. Dinoprostone transforming growth factor beta 1 Homo sapiens
4 CONCLUSION: TGF-beta1 increased the COX-2 and PGE2 level of cultured pulp cells. Dinoprostone transforming growth factor beta 1 Homo sapiens