Pub. Date : 2017 Oct
PMID : 28779263
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tunicamycin potentiates paclitaxel-induced apoptosis through inhibition of PI3K/AKT and MAPK pathways in breast cancer. | Tunicamycin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | However, tunicamycin has the ability to downregulate AKT and MAPK pathways. | Tunicamycin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Western blotting analysis confirmed that tunicamycin decreased paclitaxel-induced upregulation of survival signal pathways such as AKT and MAPK. | Tunicamycin | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | CONCLUSION: These results revealed that tunicamycin synergistically enhanced the antitumor effects of paclitaxel through potentiating apoptosis via inhibiting paclitaxel-induced elevation of AKT and MAPK pathways. | Tunicamycin | thymoma viral proto-oncogene 1 | Mus musculus |