Title : 5-Aminosalicylic acid in patients with an ileo-rectal anastomosis. A comparison of the fate of sulfasalazine and Pentasa.

Pub. Date : 1986

PMID : 2877884






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1 The pharmacokinetics of 5-aminosalicylic acid (5-ASA) from sulphasalazine (SASP) and the slow-release 5-ASA preparation Pentasa was investigated in a cross-over study in 9 otherwise healthy patients with an ileo-rectal anastomosis. Mesalamine aspartic peptidase retroviral like 1 Homo sapiens
2 The pharmacokinetics of 5-aminosalicylic acid (5-ASA) from sulphasalazine (SASP) and the slow-release 5-ASA preparation Pentasa was investigated in a cross-over study in 9 otherwise healthy patients with an ileo-rectal anastomosis. Mesalamine aspartic peptidase retroviral like 1 Homo sapiens
3 The median release of 5-ASA from SASP was 50% and from Pentasa 75%. Mesalamine aspartic peptidase retroviral like 1 Homo sapiens
4 The present findings also demonstrate that bacterial azo-reduction of SASP in patients with ileorectal anastomosis may be an adequate way to deliver 5-ASA in this type of patient. Mesalamine aspartic peptidase retroviral like 1 Homo sapiens