Title : Determination of optimized oxygen partial pressure to maximize the liver regenerative potential of the secretome obtained from adipose-derived stem cells.

Pub. Date : 2017 Aug 3

PMID : 28774345






2 Functional Relationships(s)
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1 When injected into the partially hepatectomized mice, the 1% pO2 secretome most significantly increased the number of Ki67-positive cells, reduced serum levels of proinflammatory mediators (IL-6 and TNF-alpha), and reduced serum levels of liver transaminases. PO-2 interleukin 6 Mus musculus
2 In addition, analysis of the liver specimens indicated that injection with the 1% pO2 secretome maximized the expression of the intermediate molecules of the PIP3/Akt and IL-6/STAT3 signaling pathways, all of which are known to promote liver regeneration. PO-2 interleukin 6 Mus musculus