Pub. Date : 2018 Mar
PMID : 28771725
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report here that toll-like receptor 4 (TLR4) and ABCB1 are upregulated in SKOV3 ovarian carcinoma cells that acquired resistance to the anticancer drug taxol. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | A sub-lethal dose of taxol induced ABCB1 protein expression in taxol-resistant SKOV3 cells. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | A sub-lethal dose of taxol induced ABCB1 protein expression in taxol-resistant SKOV3 cells. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Notably, the NFkappaB pathway was significantly activated by taxol, and inhibition of this pathway suppressed TLR4-regulated ABCB1 expression. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Consistent with these results, ectopic expression of TLR4 in taxol-sensitive SKOV3 cells enhanced ABCB1 expression and conferred resistance to taxol. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | These results demonstrate that taxol activates the TLR4-NFkappaB pathway which in turn induces ABCB1 gene expression. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |